News
Yerbolat joins the group as a PostDoc to work on your NWO-funded project on electron-driven reactions - Welcome Yerbolat!
Our latest paper comparing continuous and pulsed laser-based desorption (LIAD) methods is out now in Eur.Phys.J. D - well done Siwen! https://bit.ly/3cYM5tc
Our latest paper showing how the electrostatic deflector can be used as a tool for isomer-resolved spectroscopy is out now in @JPhysChem A - well done Grite! https://doi.org/10.1021/acs.jpca.2c02277
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Recent Publications
Wang, Siwen; Abma, Grite L.; Krüger, Peter; Roij, Andre; Balster, Michiel; Janssen, Niek; Horke, Daniel A.
Comparing Pulsed and Continuous Laser-Induced Acoustic Desorption (LIAD) as Sources for Intact Biomolecules Journal Article
In: Eur. Phys. J. D, vol. 76, no. 7, pp. 128, 2022, ISSN: 1434-6060, 1434-6079.
@article{wangComparingPulsedContinuous2022,
title = {Comparing Pulsed and Continuous Laser-Induced Acoustic Desorption (LIAD) as Sources for Intact Biomolecules},
author = {Siwen Wang and Grite L. Abma and Peter Kr\"{u}ger and Andre Roij and Michiel Balster and Niek Janssen and Daniel A. Horke},
url = {https://link.springer.com/10.1140/epjd/s10053-022-00459-7},
doi = {10.1140/epjd/s10053-022-00459-7},
issn = {1434-6060, 1434-6079},
year = {2022},
date = {2022-07-01},
urldate = {2022-07-25},
journal = {Eur. Phys. J. D},
volume = {76},
number = {7},
pages = {128},
abstract = {A major obstacle to the gas-phase study of larger (bio)molecular systems is the vaporisation step, that is, the introduction of intact sample molecules into the gas-phase. A promising approach is the use of laser-induced acoustic desorption (LIAD) sources, which have been demonstrated using both nanosecond pulsed and continuous desorption lasers. We directly compare here both approaches for the first time under otherwise identical conditions using adenine as a prototypical biological molecule, and study the produced molecular plumes using femtosecond multiphoton ionisation. We observe different desorption mechanisms at play for the two different desorption laser sources; however, we find no evidence in either case that the desorption process leads to fragmentation of the target molecule unless excessive desorption energy is applied. This makes LIAD a powerful approach for techniques that require high density and high purity samples in the gas-phase, such as ultrafast dynamics studies or diffraction experiments.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A major obstacle to the gas-phase study of larger (bio)molecular systems is the vaporisation step, that is, the introduction of intact sample molecules into the gas-phase. A promising approach is the use of laser-induced acoustic desorption (LIAD) sources, which have been demonstrated using both nanosecond pulsed and continuous desorption lasers. We directly compare here both approaches for the first time under otherwise identical conditions using adenine as a prototypical biological molecule, and study the produced molecular plumes using femtosecond multiphoton ionisation. We observe different desorption mechanisms at play for the two different desorption laser sources; however, we find no evidence in either case that the desorption process leads to fragmentation of the target molecule unless excessive desorption energy is applied. This makes LIAD a powerful approach for techniques that require high density and high purity samples in the gas-phase, such as ultrafast dynamics studies or diffraction experiments.
Abma, Grite L.; Kleuskens, Dries; Wang, Siwen; Balster, Michiel; Roij, Andre; Janssen, Niek; Horke, Daniel A.
Single-Color Isomer-Resolved Spectroscopy Journal Article
In: The Journal of Physical Chemistry A, vol. 126, pp. 3811–3815, 2022.
@article{abmaSinglecolorIsomerresolvedSpectroscopy2022,
title = {Single-Color Isomer-Resolved Spectroscopy},
author = {Grite L. Abma and Dries Kleuskens and Siwen Wang and Michiel Balster and Andre Roij and Niek Janssen and Daniel A. Horke},
url = {https://doi.org/10.1021/acs.jpca.2c02277},
doi = {10.1021/acs.jpca.2c02277},
year = {2022},
date = {2022-06-01},
urldate = {2022-06-01},
journal = {The Journal of Physical Chemistry A},
volume = {126},
pages = {3811\textendash3815},
abstract = {Structural isomers, such as conformers or tautomers, are
of significant importance across chemistry and biology, as they can have
different functionalities. In gas-phase experiments using molecular
beams, formation of many different isomers cannot be prevented, and
their presence significantly complicates the assignment of spectral lines.
Current isomer-resolved spectroscopic techniques heavily rely on
theoretical calculations or make use of elaborate double-resonance
schemes. We show here that isomer-resolved spectroscopy can also be
performed using a single tunable laser. In particular, we demonstrate
single-color isomer-resolved spectroscopy by utilizing electrostatic
deflection to spatially separate the isomers. We show that for 3-
aminophenol we can spatially separate the syn and anti conformers and
use these pure samples to perform high-resolution REMPI spectroscopy, making the assignment of transitions to a particular isomer trivial, without any additional a priori information. This approach allows one to add isomer specificity to any molecular-beam-based experiment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Structural isomers, such as conformers or tautomers, are
of significant importance across chemistry and biology, as they can have
different functionalities. In gas-phase experiments using molecular
beams, formation of many different isomers cannot be prevented, and
their presence significantly complicates the assignment of spectral lines.
Current isomer-resolved spectroscopic techniques heavily rely on
theoretical calculations or make use of elaborate double-resonance
schemes. We show here that isomer-resolved spectroscopy can also be
performed using a single tunable laser. In particular, we demonstrate
single-color isomer-resolved spectroscopy by utilizing electrostatic
deflection to spatially separate the isomers. We show that for 3-
aminophenol we can spatially separate the syn and anti conformers and
use these pure samples to perform high-resolution REMPI spectroscopy, making the assignment of transitions to a particular isomer trivial, without any additional a priori information. This approach allows one to add isomer specificity to any molecular-beam-based experiment.
of significant importance across chemistry and biology, as they can have
different functionalities. In gas-phase experiments using molecular
beams, formation of many different isomers cannot be prevented, and
their presence significantly complicates the assignment of spectral lines.
Current isomer-resolved spectroscopic techniques heavily rely on
theoretical calculations or make use of elaborate double-resonance
schemes. We show here that isomer-resolved spectroscopy can also be
performed using a single tunable laser. In particular, we demonstrate
single-color isomer-resolved spectroscopy by utilizing electrostatic
deflection to spatially separate the isomers. We show that for 3-
aminophenol we can spatially separate the syn and anti conformers and
use these pure samples to perform high-resolution REMPI spectroscopy, making the assignment of transitions to a particular isomer trivial, without any additional a priori information. This approach allows one to add isomer specificity to any molecular-beam-based experiment.
Awel, Salah; Lavin-Varela, Sebastian; Roth, Nils; Horke, Daniel A.; Rode, Andrei V.; Kirian, Richard A.; Küpper, Jochen; Chapman, Henry N.
Optical Funnel to Guide and Focus Virus Particles for X-Ray Diffractive Imaging Journal Article
In: Phys. Rev. Applied, vol. 17, no. 4, pp. 044044, 2022.
@article{PhysRevApplied.17.044044,
title = {Optical Funnel to Guide and Focus Virus Particles for X-Ray Diffractive Imaging},
author = {Salah Awel and Sebastian Lavin-Varela and Nils Roth and Daniel A. Horke and Andrei V. Rode and Richard A. Kirian and Jochen K\"{u}pper and Henry N. Chapman},
url = {https://link.aps.org/doi/10.1103/PhysRevApplied.17.044044},
doi = {10.1103/PhysRevApplied.17.044044},
year = {2022},
date = {2022-04-01},
journal = {Phys. Rev. Applied},
volume = {17},
number = {4},
pages = {044044},
publisher = {American Physical Society},
keywords = {},
pubstate = {published},
tppubtype = {article}
}