Light-Sheet Imaging for the Recording of Transverse Absolute Density Distributions of Gas-Phase Particle-Beams from Nanoparticle Injectors

Abstract

Imaging biological molecules in the gas-phase requires novel sample delivery methods, which generally have to be characterized and optimized to produce high-density particle beams. A non-destructive characterization method of the transverse particle beam profile is presented. It enables the characterization of the particle beam in parallel to the collection of, for instance, x-ray-diffraction patterns. As a rather simple experimental method, it requires the generation of a small laser-light sheet using a cylindrical telescope and a microscope. The working principle of this technique was demonstrated for the characterization of the fluid-dynamic-focusing behavior of 220 nm polystyrene beads as prototypical nanoparticles. The particle flux was determined and the velocity distribution was calibrated using Mie-scattering calculations.

Links

• https://www.osapublishing.org/oe/abstract.cfm?uri=oe-27-25-36580
• doi:10.1364/OE.27.036580

BibTeX (Download)

@article{Worbs:Opt.Express27:36580,
title = {Light-Sheet Imaging for the Recording of Transverse Absolute Density Distributions of Gas-Phase Particle-Beams from Nanoparticle Injectors},
author = {Lena Worbs and Lena Worbs and Jannik L\"{u}bke and Jannik L\"{u}bke and Jannik L\"{u}bke and Nils Roth and Nils Roth and Amit K. Samanta and Daniel A. Horke and Daniel A. Horke and Daniel A. Horke and Jochen K\"{u}pper and Jochen K\"{u}pper and Jochen K\"{u}pper},
url = {https://www.osapublishing.org/oe/abstract.cfm?uri=oe-27-25-36580},
doi = {10.1364/OE.27.036580},
issn = {1094-4087},
year  = {2019},
date = {2019-12-01},
urldate = {2020-07-21},
journal = {Opt. Express},
volume = {27},
number = {25},
pages = {36580--36586},
publisher = {Optical Society of America},
abstract = {Imaging biological molecules in the gas-phase requires novel sample delivery methods, which generally have to be characterized and optimized to produce high-density particle beams. A non-destructive characterization method of the transverse particle beam profile is presented. It enables the characterization of the particle beam in parallel to the collection of, for instance, x-ray-diffraction patterns. As a rather simple experimental method, it requires the generation of a small laser-light sheet using a cylindrical telescope and a microscope. The working principle of this technique was demonstrated for the characterization of the fluid-dynamic-focusing behavior of 220 nm polystyrene beads as prototypical nanoparticles. The particle flux was determined and the velocity distribution was calibrated using Mie-scattering calculations.},
keywords = {experimental design, nanoparticles, Single-particle imaging},
pubstate = {published},
tppubtype = {article}
}